Mutation

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Mutation is a passive item

Effects

  • Regular Tears fired by Isaac are turned into piercing BrimBall.png Brimstone Balls which deal 75% of his damage.
    • Brimstone Balls slide along the floor damaging enemies
    • Brimstone balls can hit the same enemy multiple times
    • Dealing damage makes the ball smaller and deal less damage
    • After hitting enemies 5 times, the ball will stop shrinking.

Interactions

  • Brimstone.png Brimstone: Multiple small brimstone balls are fired from the laser's endpoint in the opposite direction
  • Technology.png Technology: Multiple small brimstone balls are fired from Isaac in the laser's direction
  • Tech X.png Tech X: Multiple small brimstone balls are fired away from the circle
  • Dr. Fetus.png Dr. Fetus: The bomb has a brimstone ball enveloped around it dealing damage
    • The brimstone ball still gets smaller after dealing damage
  • Ludo.png Ludovico Technique: Controlled tear is turned into a brimstone ball
    • Initial damage of the ball is higher than normal but it gets smaller with each tick
    • Ball damage is slowly restored by not colliding with enemies

Overrides Mutation:

Gallery